VALIDATION OF BRIEF COGNITIVE TESTS in mild cognitive impairment, Alzheimer’s disease and dementia with Lewy bodies

....................................................................................................... 8 Sammanfattning .......................................................................................... 9 Abbreviations ............................................................................................ 11 1 Introduction to neurodegenerative diseases .................................... 13 1.1 Alzheimer’s disease ................................................................................ 13 1.1.1 Neuropsychological prediction .......................................................... 13 1.1.2 Cognitive impairment ........................................................................ 14 1.1.3 Treatment ........................................................................................... 14 1.2 Dementia with Lewy bodies ................................................................... 15 1.3 Other dementias ...................................................................................... 15 2 Brief cognitive tests ............................................................................. 17 2.1 A Quick Test of Cognitive Speed .......................................................... 17 2.1.1 Administration ................................................................................... 18 2.1.2 Scoring ............................................................................................... 18 2.1.3 Reliability .......................................................................................... 19 2.1.4 Demographic effects .......................................................................... 19 2.1.5 Correlation with brain structures ....................................................... 20 2.1.6 Associations with other measures ..................................................... 20 2.1.7 Normative data .................................................................................. 22 2.1.8 Clinical findings ................................................................................ 22 2.1.9 Comments .......................................................................................... 23 2.2 Clock drawing ......................................................................................... 24 2.2.1 Administration ................................................................................... 26 2.2.2 Scoring ............................................................................................... 27 2.2.3 Reliability .......................................................................................... 27 2.2.4 Demographic effects .......................................................................... 27 2.2.5 Correlation with brain structures ....................................................... 29 2.2.6 Associations with other measures ..................................................... 30 2.2.7 Normative data .................................................................................. 30 2.2.8 Different types of errors .................................................................... 31